Tiny cellular bubbles enable delivery of Parkinson’s drugs straight to the brain
05May

Exosomes (shown in red) deliver catalase to protect neurons (shown in black) from the effects of Parkinson’s disease.

A natural enzyme called catalase may prove hugely significant in treating neurological disorders such as Parkinson’s. These extremely potent antioxidants can tackle neuron-killing inflammation with an effectiveness unparalleled by small molecule drugs. But there’s a problem, they are big. So big that getting them through the blood-brain barrier for delivery straight to the brain is nearly impossible. But researchers have now discovered that loading them into tiny, naturally occurring bubbles allows them to sneak past the brain’s defenses, pointing to the possibility of improved treatments for such conditions.

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Publicado el 05 de May del 2015
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